Near the Mississippi River, the Ozarks are a great choice for a motorcycle getaway. Late September and October there's great fall colors, and the Bikes, Blues & BBQ weekend, when an estimated 250,000 bikers arrive. There's lots of links below for you to check out.
From Benton, take Hwy 5 west to Hwy 7, then 150 miles north on Hwy 7 to Harrison. There are local loops from Harrison listed on their website. See a larger map and directions. Harrison is a great place to find food and lodging. It's 800 miles from Marion, VA, and just over 1000 miles from Orlando, FL.
From Eureka Springs, follow Hwy 23 south to the 19 mile Pig Trail Scenic Byway, then past I-40. Make time to stop for some BBQ or fried food at the Red Hog Deli inside the I-40 Travel Center. On US71 south of Waldren, head east on Hwy 28, then south on Hwy 27 to Hwy 8, which takes you to Arkadelphia. View the larger map and directions for this 277 mile route.
On Hwy 23, the Red Hog Deli at the I-40 Travel Center (above photos) is worth a stop. I visited twice, having the BBQ pork sandwich as well as the fried catfish filet. I haven't had good catfish like that in years! In addition to the deli, you can have a seat and a waitress will take your order off the menu.
Then you can head south on 23 and ride up Mt. Magazine on Hwy 309.
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Harrison Arkansas, just south of Branson, MO on US 65, has their own motorcycle info website along with a riding guide you can request. There's routes like the Twisted Lady, with 517 curves in 90 miles, three nearby caves to be explored, and who knew there was an Elk herd in Arkansas?
The Arkansas Department of Parks & Tourism has their own motorcycling page with plenty of info, a suggested rides page, a waterfalls page, and some tank maps in PDF format. (PDF takes a minute to open.) There's even a deals & coupons page.