US219 runs from Virginia, near Blacksburg, thru scenic portions of West Virginia and Pennsylvania.
Okay, the city of Bradford, PA (Kendall Oil) isn't so scenic, but 219 is two lanes for most of this 447 miles.
You can take it on to Buffalo, NY if you're heading to visit Niagara Falls.
"From largest to smallest, the three waterfalls are the Horseshoe Falls, the American Falls and the Bridal Veil Falls. The Horseshoe Falls lie mostly on the Canadian side and the American Falls entirely on the American side, separated by Goat Island. The smaller Bridal Veil Falls are also located on the American side, separated from the other waterfalls by Luna Island."