Acadia National Park was the first National Park east of the Mississippi.
"People have been drawn to the rugged coast of Maine throughout history. Awed by its beauty and diversity, early 20th-century visionaries donated the land that became Acadia National Park. The park is home to many plants and animals, and the tallest mountain on the U.S. Atlantic coast. Today visitors come to Acadia to hike granite peaks, bike historic carriage roads, or relax and enjoy the scenery."
"Cadillac Mountain in Acadia National Park is the tallest mountain along the eastern coast of the United States. During certain times of the year, it is the first place in the U.S. to see
Bass Harbor Head Light south of Tremont off Hwy 102A
"The cliffside Bass Harbor Head Lighthouse in Acadia National Park, located in the village of Bass Harbor within Tremont, Maine in the United States, marks the entrance to Bass Harbor on the southwestern side of Mount Desert Island. The lighthouse was built of brick in 1858 on a stone foundation, stands 56 feet above mean high water and is accessible by car off Route 102A. Parking is free and is open daily from 9:00 AM to sunset."
The Jackson Laboratory on Hwy 3 south of Bar Harbor, "is an independent, nonprofit biomedical research institution, dedicated to contributing to a future of better health care based on the unique genetic makeup of each individual. With more than 1,500 employees in Bar Harbor, Maine, Sacramento, Calif. and a new genomic medicine institute in Farmington, Conn., the Laboratory's mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.  The institution is a National Cancer Institute-designated Cancer Center and has NIH centers of excellence in aging and systems genetics. The Laboratory is also the world's source for more than 7,000 strains of genetically defined mice, is home of the mouse genome database and is an international hub for scientific courses, conferences, training and education."
Just north of Mount Desert Island, pickup Maine's 27 mile Schoodic Scenic Byway on US 1. The byway contains the only mainland section of Acadia National Park.
Bold Coast Scenic Byway (click the map to enlarge it)
"The 125-miles long Bold Coast route extends from the coastal fishing community of Milbridge eastward along the coast to Lubec, the easternmost town in the United States, and then scoops around Cobscook Bay to Eastport. Visitors travel along the rocky coast, passing through iconic wild blueberry barrens; sparsely developed coastal forests; tidal marshes and freshwater bogs; the Passamaquoddy Indian Reservation; active fishing harbors; recreational trails providing opportunities to explore the natural wonders and scenic bounty; and historic villages lined with exemplary architecture and museums."
66 miles north of Gouldsboro on US 1, see the sunrise in Lubec from the easternmost town in the US. The 100 year old Inn on the Wharf offers whale watching, as well as lodging and food. Visit nearby Quoddy Head State Park, the easternmost point in the United States.
See map with directions.
West Quoddy Head lens
Photo by Liz West from Boxborough, MA
[CC-BY-2.0, via Wikimedia Commons
Next you can continue your tour 243 miles north to Madawaska, the northernmost point in New England. There is lodging available. If you have your passport, there's more hotels across the river in Edmunston, Canada.
Aroostook Scenic Hwy, Maine 11, brings you south through rural Maine along the Arrostook River. Fort Kent to Sherman (I-95) is 105 miles, so plan your gas accordingly. Maine Hwy 221 takes you the final 20 miles.
See larger map with directions.